About

I am an Irish researcher living in Philadelphia working in the area of circadian biology, aging, metabolism, and nutrition at the FitzGerald Laboratory at the Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania.

My research interests include:
(a) Circadian biology, metabolism, and ageing
(b) Regulation, safety, and efficacy of functional foods and nutraceuticals
(c) Discerning the role of lipid mediators such as eicosanoids and platelet-activating factors in inflammatory diseases.
(d) The role of a patient's nutritional status and the use of supplements during COVID-19.

Check out the webpage for research, science communication and how to make contact.

Also check out the FitzGerald Lab webpage for more info and exciting science: https://www.med.upenn.edu/fitzgeraldlab/

Publications

Milk Polar lipids: Untapped Potential for Pharmaceuticals and Nutraceuticals

Aditi Pawar, I. Zabetakis, Tanvi Gavankar, R. Lordan

PharmaNutrition, 2023

Cardiovascular Diseases and Marine Oils: A Focus on Omega-3 Polyunsaturated Fatty Acids and Polar Lipids

Cliodhna Caffrey, Anna Leamy, Ellen O’Sullivan, I. Zabetakis, R. Lordan, C. Nasopoulou

Marine Drugs, 2023

Modulation of the immune response to SARS-CoV-2 vaccination by NSAIDs.

C. Skarke, R. Lordan, Kayla Barekat, A. Naik, D. Mathew, T. Ohtani, A. Greenplate, Gregory R Grant, N. Lahens, S. Gouma, Elizabeth Troisi, Arjun Sengupta, A. Weljie, Wenzhao Meng, E. L. Luning Prak, Kendall A. Lundgreen, Paul Bates, H. Meng, G. FitzGerald

Journal of Pharmacology and Experimental Therapeutics, 2023

Modulation of the Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination by Nonsteroidal Anti-Inflammatory Drugs

Journal of Pharmacology and Experimental Therapeutics, 2023

Abstracts from the Student Medical Summit 2023

Ireland Dublin, February, Mowa Ayibiowu, Jia Lin, Izabelle Siqueira, Sarah J. Pol, Taylor Robertson, Joanna Mitchell, Sara Ahola Kohut, A. J. Donma, M. Seifert-Hansen, Heather Telfer, Samantha J Anthony, Ainsley Matthewson, Ryan Chow, Georges Khalaf, Nandini Biyani, Sejal Khandelwal, Evan Tannenbaum, Charlotte McCreery, R. Lordan, Matthew Thomas, Sarah L. Teegarden, Soon‑Yew Tang, Carsten Skarke, Garret A. FitzGerald, Salma Youssef

BMC Proceedings, 2023

The Circadian Biology of Heart Failure

Nadim El Jamal, R. Lordan, S. Teegarden, T. Grosser, G. FitzGerald

2023

The dark side of shift work: circadian misalignment of skeletal muscle.

R. Lordan

Nature Reviews Endocrinology, 2023

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Projects

Circadian Regulation of Metabolism and Aging

2020 - Present: This project aims to understand the role of circadian misalignment and its contribution to metabolic diseases and aging, with a focus on Bmal1.

Lipid Mediators of Inflammation

2016 - Present: Platelet-activating factor (PAF), prostaglandins, and leukotrienes play a pivotal role in inflammatory signaling. We are interested in the development of novel therapeutic agents targeting these inflammatory mediators.

COVID-19 Research and Review Consortium

2020 - 2021: COVID-19 Review Consortium at UPenn. Our aim is to distill the existing COVID-19 literature into reviews that document the most reliable research to date in the areas of pathogenesis, therapeutics, prophylactics, and diagnostics.

2018 - 2021: Heart Healthy Salmon Nutraceuticals

The aim of this project was to assess the antioxidant properties and elucidate the structures of antithrombotic polar lipids from farmed Atlantic salmon using C30RP-UHPLC-HRAM-MS/MS for the development of novel nutraceuticals.