Dr Ronan Lordan

Available to discuss new collaborations, science outreach or speaking opportunities. Feel free to make contact via email or twitter.



Institute for Translational Medicine and Therapeutics

Perelman School of Medicine, University of Pennsylvania



COVID-19 Research and Review Consortium


Modulation of the immune response to SARS-CoV-2 vaccination by NSAIDs

Evidence is scarce to guide the use of nonsteroidal anti-inflammatory drugs (NSAIDs) to mitigate SARS-CoV-2 vaccine related adverse effects, given the possibility of blunting the desired immune response. In this pilot study, we deeply phenotyped a small number of volunteers who did or did not take NSAIDs concomitant with SARS-CoV-2 immunizations to seek initial information on the immune response. A SARS-CoV-2 vaccine specific RBD-IgG antibody response and efficacy in the evoked neutralization titers were evident irrespective of concomitant NSAID consumption. Given the sample size, only a large and consistent signal of immunomodulation would have been detectable, and this was not apparent. However, the information gathered may inform the design of a definitive clinical trial. 

COVID-19 Review Consortium:

The COVID-19 review consortium was initiated by Casey Greene's team in response to the coronavirus disease 2019 (COVID-19) pandemic. Led by Dr Halie Rando, the consortium has created a living review of which sections have been peer reviewed and published. Some of the main outputs of the review consortium are presented below.

SARS-CoV-2 and COVID-19:  An Evolving Review of Diagnostics and Therapeutics
https://greenelab.github.io/covid19-review/

Publications


Modulation of the immune response to SARS-CoV-2 vaccination by NSAIDs.


C. Skarke, R. Lordan, Kayla Barekat, A. Naik, D. Mathew, T. Ohtani, A. Greenplate, Gregory R Grant, N. Lahens, S. Gouma, Elizabeth Troisi, Arjun Sengupta, A. Weljie, Wenzhao Meng, E. L. Luning Prak, Kendall A. Lundgreen, Paul Bates, H. Meng, G. FitzGerald

Journal of Pharmacology and Experimental Therapeutics, 2023


Twitter-based crowdsourcing: What kind of measures can help to end the COVID-19 pandemic faster?


Himel Mondal, Emil D. Parvanov, Rajeev K. Singla, R. Rayan, F. Nawaz, V. Ritschl, F. Eibensteiner, Chandragiri Siva Sai, M. Cenanovic, Hari Prasad Devkota, M. Hribersek, Ronita De, E. Klager, M. Kletečka-Pulker, S. Völkl-Kernstock, G. Khalid, R. Lordan, M. Găman, Bairong Shen, T. Stamm, H. Willschke, Atanas G. Atanasov

Frontiers in Medicine, 2022


Application of Traditional Vaccine Development Strategies to SARS-CoV-2


H. M. Rando, R. Lordan, Alexandra J. Lee, A. Naik, Nils Wellhausen, Elizabeth A Sell, Likhitha Kolla, COVID-19 Review Consortium, A. Gitter, Casey S. Greene

2022


The Coming of Age of Nucleic Acid Vaccines during COVID-19


H. M. Rando, R. Lordan, Likhitha Kolla, Elizabeth A Sell, Alexandra J. Lee, Nils Wellhausen, A. Naik, J. Kamil, A. Gitter, Casey S. Greene, the COVID-19 Review Consortium

2022


Correction for Rando et al., “Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure”


H. Rando, A. Maclean, Alexandra J. Lee, R. Lordan, Sandipan Ray, Vikas Bansal, Ashwin N. Skelly, Elizabeth A Sell, J. Dziak, Lamonica Shinholster, Lucy D’Agostino McGowan, Marouen Ben Guebila, Nils Wellhausen, S. Knyazev, S. Boca, Stephen Capone, Yanjun Qi, YoSon Park, David Mai, Yuchen Sun, J. Boerckel, Christian Brueffer, James Brian Byrd, J. Kamil, Jinhui Wang, Ryan Velazquez, G. Szeto, J. Barton, R. Goel, S. Mangul, Tiago Lubiana, A.B.D. Gitter, C. Greene

mSystems, 2022


Molecular and Serologic Diagnostic Technologies for SARS-CoV-2


H. Rando, Christian Brueffer, R. Lordan, A. A. Dattoli, D. Manheim, J. Meyer, Ariel I. Mundo, Dimitri Perrin, David Mai, Nils Wellhausen, A.B.D. Gitter, Casey S. Greene

ArXiv, 2022


Probiotics: A gut response to the COVID-19 pandemic but what does the evidence show?


Sandrayee Brahma, A. Naik, R. Lordan

Clinical Nutrition ESPEN, 2022


Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure


Halie M. Rando, Adam L. MacLean, Alexandra J. Lee, Ronan Lordan, Sandipan Ray, Vikas Bansal, Ashwin N. Skelly, Elizabeth Sell, John J. Dziak, Lamonica Shinholster, Lucy D’Agostino McGowan, Marouen Ben Guebila, Nils Wellhausen, Sergey Knyazev, Simina M. Boca, Stephen Capone, Yanjun Qi, YoSon Park, David Mai, Yuchen Sun, Joel D. Boerckel, Christian Brueffer, James Brian Byrd, Jeremy P. Kamil, Jinhui Wang, Ryan Velazquez, Gregory L. Szeto, John P. Barton, Rishi Raj Goel, Serghei Mangul, Tiago Lubiana, COVID-19 Review Consortium, Anthony Gitter, Casey S. Greene

mSystems, vol. 6(5), 2021


Identification and Development of Therapeutics for COVID-19


H. Rando, Nils Wellhausen, Soumita Ghosh, Alexandra J. Lee, A. A. Dattoli, Fengling Hu, J. B. Byrd, Diane N. Rafizadeh, R. Lordan, Yanjun Qi, Yuchen Sun, Christian Brueffer, J. Field, Marouen Ben Guebila, N. Jadavji, Ashwin N. Skelly, Bharath Ramsundar, Jinhui Wang, R. Goel, YoSon Park, Vikas John P. Simina M. Joel D. Christian James Brian St Bansal Barton Boca Boerckel Brueffer Byrd Capone D, S. Boca, A. Gitter, C. Greene

mSystems, 2021


SARS-CoV-2 and COVID-19: An Evolving Review of Diagnostics and Therapeutics


Halie M. Rando, Casey S. Greene, Michael P. Robson, Simina M. Boca, Nils Wellhausen, Ronan Lordan, Christian Brueffer, Sadipan Ray, Lucy D 'Agostino McGowan, Anthony Gitter, Anthony Gitter, Ronnie M. Russell, Anna Ada Dattoli, Ryan Velazquez, John P. Barton, Jeffrey M. Field, Bharath Ramsundar, Adam L. MacLean, Alexandra J. Lee, Fengling Hu, Nafisa M. Jadavji, Nafisa M. Jadavji, Elizabeth Sell, Jinhui Wang, Diane N. Rafizadeh, Ashwin N. Skelly, Marouen Ben Guebila, Likhitha Kolla, David Manheim, Soumita Ghosh, Matthias Fax, James Brian Byrd, YoSon Park, Yael Evelyn Marshall, Vikas Bansal, Stephen Capone, John J. Dziak

Manubot, 2020 Jun 6


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