APA
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Skarke, C., Lordan, R., Barekat, K., Naik, A., Mathew, D., Ohtani, T., … FitzGerald, G. (2023). Modulation of the immune response to SARS-CoV-2 vaccination by NSAIDs. Journal of Pharmacology and Experimental Therapeutics.
Chicago/Turabian
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Skarke, C., R. Lordan, Kayla Barekat, A. Naik, D. Mathew, T. Ohtani, A. Greenplate, et al. “Modulation of the Immune Response to SARS-CoV-2 Vaccination by NSAIDs.” Journal of Pharmacology and Experimental Therapeutics (2023).
MLA
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Skarke, C., et al. “Modulation of the Immune Response to SARS-CoV-2 Vaccination by NSAIDs.” Journal of Pharmacology and Experimental Therapeutics, 2023.
BibTeX Click to copy
@article{c2023a,
title = {Modulation of the immune response to SARS-CoV-2 vaccination by NSAIDs.},
year = {2023},
journal = {Journal of Pharmacology and Experimental Therapeutics},
author = {Skarke, C. and Lordan, R. and Barekat, Kayla and Naik, A. and Mathew, D. and Ohtani, T. and Greenplate, A. and Grant, Gregory R and Lahens, N. and Gouma, S. and Troisi, Elizabeth and Sengupta, Arjun and Weljie, A. and Meng, Wenzhao and Prak, E. L. Luning and Lundgreen, Kendall A. and Bates, Paul and Meng, H. and FitzGerald, G.}
}
Evidence is scarce to guide the use of nonsteroidal anti-inflammatory drugs (NSAIDs) to mitigate SARS-CoV-2 vaccine related adverse effects, given the possibility of blunting the desired immune response. In this pilot study, we deeply phenotyped a small number of volunteers who did or did not take NSAIDs concomitant with SARS-CoV-2 immunizations to seek initial information on the immune response. A SARS-CoV-2 vaccine specific RBD-IgG antibody response and efficacy in the evoked neutralization titers were evident irrespective of concomitant NSAID consumption. Given the sample size, only a large and consistent signal of immunomodulation would have been detectable, and this was not apparent. However, the information gathered may inform the design of a definitive clinical trial. Here, we report a series of divergent omics signals that invite additional hypotheses testing. Significance Statement A SARS-CoV-2 vaccine specific immune response was evident irrespective of concomitant NSAID consumption in a clinical pilot study of small sample size.