Journal article
H. M. Rando, R. Lordan, Alexandra J. Lee, A. Naik, Nils Wellhausen, Elizabeth A Sell, Likhitha Kolla, COVID-19 Review Consortium, A. Gitter, Casey S. Greene
2022
2022
Semantic Scholar
ArXiv
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APA
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Rando, H. M., Lordan, R., Lee, A. J., Naik, A., Wellhausen, N., Sell, E. A., … Greene, C. S. (2022). Application of Traditional Vaccine Development Strategies to SARS-CoV-2.
Chicago/Turabian
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Rando, H. M., R. Lordan, Alexandra J. Lee, A. Naik, Nils Wellhausen, Elizabeth A Sell, Likhitha Kolla, COVID-19 Review Consortium, A. Gitter, and Casey S. Greene. “Application of Traditional Vaccine Development Strategies to SARS-CoV-2” (2022).
MLA
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Rando, H. M., et al. Application of Traditional Vaccine Development Strategies to SARS-CoV-2. 2022.
BibTeX Click to copy
@article{h2022a,
title = {Application of Traditional Vaccine Development Strategies to SARS-CoV-2},
year = {2022},
author = {Rando, H. M. and Lordan, R. and Lee, Alexandra J. and Naik, A. and Wellhausen, Nils and Sell, Elizabeth A and Kolla, Likhitha and Consortium, COVID-19 Review and Gitter, A. and Greene, Casey S.}
}
Abstract
Over the past 150 years, vaccines have revolutionized the relationship between people and disease. During the COVID-19 pandemic, technologies such as mRNA vaccines have received significant attention due to their novelty and successes. However, more traditional vaccine development platforms have also been applied against SARS-CoV-2, yielding important tools in the worldwide fight against the virus. A variety of approaches have been used to develop COVID-19 vaccines that are now authorized for use in countries around the world. In this review, we highlight strategies that focus on the viral capsid outwards, rather than on the nucleic acids inside. Such approaches broadly fall into two categories: whole-virus vaccines and subunit vaccines. Whole-virus vaccine approaches use the virus itself, either in an inactivated or attenuated state. Subunit vaccines isolate an immunogenic component of the virus using various strategies that is then introduced through vaccination. We highlight specific vaccine candidates that utilize these approaches in