APA
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Skarke, C., Lahens, N., Mrcela, A., Olsson, N., Glessner, J., Naik, A., … Fitzgerald, G. (2026). Age and the Diurnal Oscillatory Features of the Human Chronobiome. MedRxiv.
Chicago/Turabian
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Skarke, C., N. Lahens, A. Mrcela, N. Olsson, Joe Glessner, A. Naik, K. N. Theken, et al. “Age and the Diurnal Oscillatory Features of the Human Chronobiome.” medRxiv (2026).
MLA
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Skarke, C., et al. “Age and the Diurnal Oscillatory Features of the Human Chronobiome.” MedRxiv, 2026.
BibTeX Click to copy
@article{c2026a,
title = {Age and the Diurnal Oscillatory Features of the Human Chronobiome},
year = {2026},
journal = {medRxiv},
author = {Skarke, C. and Lahens, N. and Mrcela, A. and Olsson, N. and Glessner, Joe and Naik, A. and Theken, K. N. and Chivily, Caroline and Douglas, Declan and Hess, Kyle N. and Gaun, Aleksandr and Moustafa, Ahmed M. and Daniel, Scott and Bittinger, Kyle and Teegarden, Sarah L. and Lordan, R. and Jamal, N. El and Meng, Hu and Hollingsworth, Taylor and Woolfork, Ashley and Sengupta, Arjun and Brooks, Thomas S. and Weljie, A. and Grant, G. and O'Brien, J. and McAllister, Fiona E. and Melamud, E. and Fitzgerald, G.}
}
The molecular clock regulates diverse aspects of human biology. As people age, diurnal rhythms deteriorate, most evidently in the daytime napping and nighttime waking of older individuals. To understand how temporal deconsolidation of oscillatory networks could contribute to age-related disease expression, we studied the chronobiome at unprecedented depth in young and old apparently healthy individuals. Transomic integration segregated age groups and identified candidate mechanisms by which oscillatory function might contribute to age dependent distinctions. In an orthogonal approach, we validated as true cyclers many proteins identified in the UK Biobank as predictors of health and disease outcomes. Here, age-specific alterations in the cycling proteome across disease phenotypes is consistent with our hypothesis that deconsolidated circadian programs associate with increased susceptibility to age-related disease.