Dr Ronan Lordan

Available to discuss new collaborations, science outreach or speaking opportunities. Feel free to make contact via email or twitter.



Institute for Translational Medicine and Therapeutics

Perelman School of Medicine, University of Pennsylvania



Oil from Mullet Roe Byproducts: Effect of Oil Extraction Method on Human Erythrocytes and Platelets


Journal article


Ioannis Tsamesidis, Paraskevi Tzika, D. Georgiou, Aggelos Charisis, Sakshi Hans, R. Lordan, I. Zabetakis, Eleni P Kalogianni
Foods, 2023

Semantic Scholar DOI PubMedCentral PubMed
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APA   Click to copy
Tsamesidis, I., Tzika, P., Georgiou, D., Charisis, A., Hans, S., Lordan, R., … Kalogianni, E. P. (2023). Oil from Mullet Roe Byproducts: Effect of Oil Extraction Method on Human Erythrocytes and Platelets. Foods.


Chicago/Turabian   Click to copy
Tsamesidis, Ioannis, Paraskevi Tzika, D. Georgiou, Aggelos Charisis, Sakshi Hans, R. Lordan, I. Zabetakis, and Eleni P Kalogianni. “Oil from Mullet Roe Byproducts: Effect of Oil Extraction Method on Human Erythrocytes and Platelets.” Foods (2023).


MLA   Click to copy
Tsamesidis, Ioannis, et al. “Oil from Mullet Roe Byproducts: Effect of Oil Extraction Method on Human Erythrocytes and Platelets.” Foods, 2023.


BibTeX   Click to copy

@article{ioannis2023a,
  title = {Oil from Mullet Roe Byproducts: Effect of Oil Extraction Method on Human Erythrocytes and Platelets},
  year = {2023},
  journal = {Foods},
  author = {Tsamesidis, Ioannis and Tzika, Paraskevi and Georgiou, D. and Charisis, Aggelos and Hans, Sakshi and Lordan, R. and Zabetakis, I. and Kalogianni, Eleni P}
}

Abstract

Background: The valorization of byproducts to obtain high nutritional value foods is of utmost importance for our planet where the population is booming. Among these products are oils rich in ω-3 fatty acids produced from fishery byproducts. Recently, mullet roe oil from roe byproducts was produced that was rich in the ω-3 fatty acids eicosatetraenoic acid (EPA) and docosahexaenoic acid (DHA). Oils are customarily characterized for their composition and degree of oxidation but little is known of their biological effects, especially the effect of the extraction method. Methods: The purpose of this study was to evaluate the effects of freshly extracted mullet roe oil from mullet roe byproducts and the effect of the extraction method on human red blood cells (hRBCs) and platelets. To this end, the hemocompatibility (cytotoxicity), oxidative effects, and erythrocyte membrane changes were examined after 1 and 24 h of incubation. Antiplatelet effects were also assessed in vitro. Results: The expeller press oil extraction method and alcalase-assisted extraction produced the most biocompatible oils, as shown by hemocompatibility measurements and the absence of erythrocyte membrane alterations. Solvent extracts and protease-assisted extraction oils resulted in the rupture of red blood cells at different examined dilutions, creating hemolysis. Conclusions: It seems that the proper functioning of oil–erythrocyte interactions cannot be explained solely by ROS. Further investigations combining chemical analysis with oil–cell interactions could be used as an input to design high nutritional value oils using green extraction technologies. All samples exhibited promising antiplatelet and antiblood clotting effects in vitro.


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