APA
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Skarke, C., Lordan, R., Barekat, K., Naik, A., Mathew, D., Ohtani, T., … FitzGerald, G. (2023). Modulation of the Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination by Nonsteroidal Anti-Inflammatory Drugs. Journal of Pharmacology and Experimental Therapeutics.
Chicago/Turabian
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Skarke, C., R. Lordan, Kayla Barekat, A. Naik, D. Mathew, T. Ohtani, A. Greenplate, et al. “Modulation of the Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination by Nonsteroidal Anti-Inflammatory Drugs.” Journal of Pharmacology and Experimental Therapeutics (2023).
MLA
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Skarke, C., et al. “Modulation of the Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination by Nonsteroidal Anti-Inflammatory Drugs.” Journal of Pharmacology and Experimental Therapeutics, 2023.
BibTeX Click to copy
@article{c2023a,
title = {Modulation of the Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination by Nonsteroidal Anti-Inflammatory Drugs},
year = {2023},
journal = {Journal of Pharmacology and Experimental Therapeutics},
author = {Skarke, C. and Lordan, R. and Barekat, Kayla and Naik, A. and Mathew, D. and Ohtani, T. and Greenplate, A. and Grant, Gregory R and Lahens, N. and Gouma, S. and Troisi, Elizabeth and Sengupta, Arjun and Weljie, A. and Meng, Wenzhao and Prak, E. L. Luning and Lundgreen, Kendall A. and Bates, Paul and Meng, H. and FitzGerald, G.}
}
Evidence is scarce to guide the use of nonsteroidal anti-inflammatory drugs (NSAIDs) to mitigate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine–related adverse effects, given the possibility of blunting the desired immune response. In this pilot study, we deeply phenotyped a small number of volunteers who did or did not take NSAIDs concomitant with SARS-CoV-2 immunizations to seek initial information on the immune response. A SARS-CoV-2 vaccine–specific receptor binding domain (RBD) IgG antibody response and efficacy in the evoked neutralization titers were evident irrespective of concomitant NSAID consumption. Given the sample size, only a large and consistent signal of immunomodulation would have been detectable, and this was not apparent. However, the information gathered may inform the design of a definitive clinical trial. Here we report a series of divergent omics signals that invites additional hypotheses testing. SIGNIFICANCE STATEMENT The impact of nonsteroidal anti-inflammatory drugs (NSAIDs) on the immune response elicited by repeat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunizations was profiled by immunophenotypic, proteomic, and metabolomic approaches in a clinical pilot study of small sample size. A SARS-CoV-2 vaccine–specific immune response was evident irrespective of concomitant NSAID consumption. The information gathered may inform the design of a definitive clinical trial.