Dr Ronan Lordan

Available to discuss new collaborations, science outreach or speaking opportunities. Feel free to make contact via email or twitter.

Curriculum vitae

Institute for Translational Medicine and Therapeutics

Perelman School of Medicine, University of Pennsylvania

The Circadian Biology of Heart Failure

Journal article

Nadim El Jamal, R. Lordan, S. Teegarden, T. Grosser, G. FitzGerald

Semantic Scholar DOI


APA   Click to copy
Jamal, N. E., Lordan, R., Teegarden, S., Grosser, T., & FitzGerald, G. (2023). The Circadian Biology of Heart Failure.

Chicago/Turabian   Click to copy
Jamal, Nadim El, R. Lordan, S. Teegarden, T. Grosser, and G. FitzGerald. “The Circadian Biology of Heart Failure” (2023).

MLA   Click to copy
Jamal, Nadim El, et al. The Circadian Biology of Heart Failure. 2023.

BibTeX   Click to copy

  title = {The Circadian Biology of Heart Failure},
  year = {2023},
  author = {Jamal, Nadim El and Lordan, R. and Teegarden, S. and Grosser, T. and FitzGerald, G.}


Driven by autonomous molecular clocks that are synchronized by a master pacemaker in the suprachiasmatic nucleus, cardiac physiology fluctuates in diurnal rhythms that can be partly or entirely circadian. Cardiac contractility, metabolism, and electrophysiology, all have diurnal rhythms, as does the neurohumoral control of cardiac and kidney function. In this review, we discuss the evidence that circadian biology regulates cardiac function, how molecular clocks may relate to the pathogenesis of heart failure, and how chronotherapeutics might be applied in heart failure. Disrupting molecular clocks can lead to heart failure in animal models, and the myocardial response to injury seems to be conditioned by the time of day. Human studies are consistent with these findings, and they implicate the clock and circadian rhythms in the pathogenesis of heart failure. Certain circadian rhythms are maintained in patients with heart failure, a factor that can guide optimal timing of therapy. Pharmacologic and nonpharmacologic manipulation of circadian rhythms and molecular clocks show promise in the prevention and treatment of heart failure.


Follow this website

You need to create an Owlstown account to follow this website.

Sign up

Already an Owlstown member?

Log in