Dr Ronan Lordan

Available to discuss new collaborations, science outreach or speaking opportunities. Feel free to make contact via email or twitter.



Institute for Translational Medicine and Therapeutics

Perelman School of Medicine, University of Pennsylvania



Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients


Journal article


Rajendran Harishkumar, S. Hans, Janelle E. Stanton, A. Grabrucker, R. Lordan, I. Zabetakis
Nutrients, 2022

Semantic Scholar DOI PubMedCentral PubMed
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APA   Click to copy
Harishkumar, R., Hans, S., Stanton, J. E., Grabrucker, A., Lordan, R., & Zabetakis, I. (2022). Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients. Nutrients.


Chicago/Turabian   Click to copy
Harishkumar, Rajendran, S. Hans, Janelle E. Stanton, A. Grabrucker, R. Lordan, and I. Zabetakis. “Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients.” Nutrients (2022).


MLA   Click to copy
Harishkumar, Rajendran, et al. “Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients.” Nutrients, 2022.


BibTeX   Click to copy

@article{rajendran2022a,
  title = {Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients},
  year = {2022},
  journal = {Nutrients},
  author = {Harishkumar, Rajendran and Hans, S. and Stanton, Janelle E. and Grabrucker, A. and Lordan, R. and Zabetakis, I.}
}

Abstract

Platelet-activating factor (PAF) is a lipid mediator that interacts with its receptor (PAF-R) to carry out cell signalling. However, under certain conditions the binding of PAF to PAF-R leads to the activation of pro-inflammatory and prothrombotic pathways that have been implicated in the onset and development of atherosclerotic cardiovascular diseases (CVD) and inflammatory diseases. Over the past four decades, research has focused on the identification and development of PAF-R antagonists that target these inflammatory diseases. Research has also shown that dietary factors such as polar lipids, polyphenols, and other nutrient constituents may affect PAF metabolism and PAF-R function through various mechanisms. In this review we focus on the inhibition of PAF-R and how this may contribute to reducing cardiovascular disease risk. We conclude that further development of PAF-R inhibitors and human studies are required to investigate how modulation of the PAF-R may prevent the development of atherosclerotic cardiovascular disease and may lead to the development of novel therapeutics.


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